Weiland O, Niklasson B, Berg R, Lundbergh P, Tideström L
Scand J Gastroenterol. 1981;16(8):967-72. doi: 10.3109/00365528109181012.
This study was performed to investigate the efficiency of 5 ml of 16.5% immunoglobulin (Ig) with an antibody titer against hepatitis A (anti-HAV) of 1:4000, using the HAVAB RIA technique, as pre-infection prophylaxis in 610 Swedish UN soldiers stationed in Sinai for 6 months. Sera were collected from 553 of these soldiers before, during, and after their service and were tested by the HAVAB technique for anti-HAV. Only 13 of 553 (2.4%) were immune before their service. During the first 5 months in Sinai, only one subclinical case of hepatitis A occurred among the men. Thereafter, two subclinical and four clinical cases occurred, although one of the subclinical cases and the four clinical ones did not occur until after the 6-month period. Thus, the Ig prophylaxis scheme used seems to offer almost complete passive protection for 5 months.
本研究旨在采用甲型肝炎放射免疫分析（HAVAB RIA）技术，调查5毫升抗体效价为1:4000的16.5%免疫球蛋白（Ig）对610名驻扎在西奈半岛6个月的瑞典联合国士兵进行感染前预防的效果。在这些士兵服役前、服役期间和服役后采集了553人的血清，并采用HAVAB技术检测抗甲型肝炎病毒（anti-HAV）。553人中只有13人（2.4%）在服役前具有免疫力。在西奈半岛的头5个月里，这些人中仅出现1例甲型肝炎亚临床病例。此后，又出现了2例亚临床病例和4例临床病例，不过其中1例亚临床病例和4例临床病例直到6个月期限结束后才出现。因此，所采用的免疫球蛋白预防方案似乎能在5个月内提供几乎完全的被动保护。
