急性白血病患者白细胞中5-甲酰四氢叶酸环化脱水酶活性的细胞化学证明
Cytochemical demonstration of 5-formyl-tetrahydrofolate cyclodehydrase activity in leucocytes of patients with acute leukaemia.
作者信息
Tzortzatou-Stathopoulou F, Zannos-Mariolea L, Karayiannis P, Pallis I, Matsaniotis N
出版信息
Scand J Haematol. 1981 May;26(5):393-7. doi: 10.1111/j.1600-0609.1981.tb01680.x.
The activity of 5-formyl-tetrahydrofolate cyclodehydrase has been studied cytochemically in leucocytes of children with acute leukaemia. Comparison of enzymatic activity in the same types of cells showed no significant variation between normal controls and the patients with acute leukaemia. The blast cells were weakly positive or negative. This finding is of very interest as the blast cells are capable of division. Probably the enzyme appears in the blast cells at some stage of the cell cycle. 2 populations of lymphocytes were observed, 1 positive with a few granules and 1 negative. A reduction of enzyme activity was observed after prophylactic cranial irradiation and methotrexate decreased enzyme activity in some patients.
已采用细胞化学方法研究了急性白血病患儿白细胞中5-甲酰四氢叶酸环化脱水酶的活性。对相同类型细胞中的酶活性进行比较后发现，正常对照组与急性白血病患者之间无显著差异。原始细胞呈弱阳性或阴性。这一发现非常有趣，因为原始细胞具有分裂能力。该酶可能在细胞周期的某个阶段出现在原始细胞中。观察到两类淋巴细胞，一类呈阳性，有少量颗粒，另一类呈阴性。预防性颅脑照射后观察到酶活性降低，甲氨蝶呤使部分患者的酶活性下降。
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