高剂量环磷酰胺给药后大鼠恢复过程中胶原蛋白的合成与溶解性

Synthesis and solubility of collagen in rats during recovery after high-dose cyclophosphamide administration.

作者信息

Wie H, Beck E I

出版信息

Acta Pharmacol Toxicol (Copenh). 1981 Apr;48(4):294-9. doi: 10.1111/j.1600-0773.1981.tb01624.x.

DOI:10.1111/j.1600-0773.1981.tb01624.x

Abstract

The metabolism of collagen and mineral was studied during a nine-day postmedicational period in young, male rats receiving high-dose intraperitoneal cyclophosphamide treatment every second day for 12 days. Two days after ending medication the white blood cell counts (WBC) were reduced by about 70%. Both synthesis and solubility of collagen were suppressed by the present medication 2 days after termination of treatment. This suppression continued throughout the 9-day postmedicational period in bones, whereas in connective tissue of porous, ceramic implants both total collagen and the amount of salt soluble collagen regained normal values 9 days after cessation of treatment. Increased mineralization was found 2 days after ending medication and this high degree of mineralization persisted during the postmedicational period studied. Serum albumin levels were reduced and no increases were detected during the postmedicational period. The suggestion is made that the general protein synthesis is affected by high-dose cyclophosphamide administration.

摘要

在为期12天的时间里，每隔一天给年轻雄性大鼠腹腔注射高剂量环磷酰胺进行治疗，之后对其进行为期九天的停药期观察，研究胶原蛋白和矿物质的代谢情况。停药两天后，白细胞计数（WBC）降低了约70%。治疗终止两天后，当前药物抑制了胶原蛋白的合成和溶解性。在停药后的9天时间里，骨骼中的这种抑制作用持续存在，而在多孔陶瓷植入物的结缔组织中，总胶原蛋白和盐溶性胶原蛋白的量在停药9天后恢复到正常值。停药两天后发现矿化增加，并且在研究的停药期内这种高度矿化持续存在。血清白蛋白水平降低，在停药期未检测到升高。有人认为高剂量环磷酰胺给药会影响一般蛋白质合成。