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醋酸甲地孕酮在某些猫科动物皮肤病问题中的应用。

The use of megestrol acetate in some feline dermatological problems.

作者信息

Gosselin Y, Chalifoux A, Papageorges M

出版信息

Can Vet J. 1981 Dec;22(12):382-4.

PMID:7337916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1790016/
Abstract

Twenty-one cats were treated with megestrol acetate because they were showing clinical signs associated with one of the following problems: eosinophilic ulcer, eosinophilic plaque, neurodermatitis, endocrine alopecia and miliary dermatitis. The dosage schedule was 5 mg orally per day per cat for seven days, then 5 mg every three days for 21 days. In all cats, we noted a good improvement of the lesions as soon as treatment was started. In 25% of the patients, one treatment schedule was sufficient to control the skin disease for at least 18 months. In the remaining 75%, two treatment schedules and/or a maintenance dosage had to be established.Side effects encountered were increased appetite, personality changes and depression.

摘要

21只猫因出现与以下问题之一相关的临床症状而接受醋酸甲地孕酮治疗:嗜酸性溃疡、嗜酸性斑块、神经性皮炎、内分泌性脱毛和粟粒性皮炎。给药方案为每只猫每天口服5毫克,持续7天,然后每三天口服5毫克,持续21天。在所有猫中,我们注意到治疗一开始病变就有明显改善。25%的患者,一个治疗方案就足以控制皮肤病至少18个月。在其余75%的患者中,必须制定两个治疗方案和/或维持剂量。出现的副作用包括食欲增加、性格改变和抑郁。

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本文引用的文献

1
The excretion of megestrol acetate by beagle bitches.比格犬母犬对醋酸甲地孕酮的排泄情况。
Vet Rec. 1970 Mar 7;86(10):287-8. doi: 10.1136/vr.86.10.287.
2
Progestagens in bitches: a review.母犬体内的孕激素:综述
J Small Anim Pract. 1970 Dec;11(12):759-78. doi: 10.1111/j.1748-5827.1970.tb05587.x.
3
Feline miliary dermatitis.猫粟粒性皮炎
J Small Anim Pract. 1972 Dec;13(12):709-10. doi: 10.1111/j.1748-5827.1972.tb06826.x.
4
Practical cryosurgery--an introduction for small-animal clinicians.实用冷冻手术——给小动物临床医生的介绍
J Small Anim Pract. 1974 Dec;15(12):715-25. doi: 10.1111/j.1748-5827.1974.tb05657.x.
5
Megestrol acetate for estrus postponement in the bitch.醋酸甲地孕酮用于母犬发情推迟
J Am Vet Med Assoc. 1975 Aug 15;167(4):285-7.
6
Cryosurgical treatment of cancerous and noncancerous diseases of dogs, horses, and cats.犬、马和猫的癌症及非癌症疾病的冷冻手术治疗。
J Am Vet Med Assoc. 1976 Jul 15;169(2):201-7.
7
The oral administration of megestrol acetate to postpone oestrus in cats.
Nord Vet Med. 1977 Jun;29(6):287-91.
8
Eosinophilic granulomas in cats.猫的嗜酸性肉芽肿
Vet Rec. 1977 Mar 19;100(12):251. doi: 10.1136/vr.100.12.251.
9
Eosinophilic granulomas in cats.猫的嗜酸性肉芽肿
Vet Rec. 1977 Apr 9;100(15):327. doi: 10.1136/vr.100.15.327-b.
10
Eosinophilic granuloma (rodent ulcer) in the cat.
Vet Rec. 1977 Feb;100(8):159. doi: 10.1136/vr.100.8.159.