伤寒感染期间对伤寒沙门氏菌脂多糖和蛋白质抗原的抗体反应。II. 用放射免疫测定法测量肠道抗体。
Antibody response to the lipopolysaccharide and protein antigens of Salmonella typhi during typhoid infection. II. Measurement of intestinal antibodies by radioimmunoassay.
作者信息
Chau P Y, Tsang R S, Lam S K, La Brooy J T, Rowley D
出版信息
Clin Exp Immunol. 1981 Dec;46(3):515-20.
Antibodies to the lipopolysaccharide (LPS) and protein antigens of S. typhi in secretions of small intestine obtained from 12 typhoid patients, four typhoid carriers and 16 non-typhoid control subjects were measured by a solid-phase radioimmunoassay technique. Intestinal secretions obtained from typhoid patients as a group had significantly higher anti-LPS and anti-protein antibodies than those from the control group. These antibodies were both IgM and IgA classes. There was no correlation between the IgM or IgA antibody levels in serum and those in the intestinal secretions. In the intestinal secretions obtained from typhoid carriers, on the other hand, only IgA-class antibodies to the LPS and protein antigens of S. typhi were present at high levels.
采用固相放射免疫测定技术，检测了12例伤寒患者、4例伤寒带菌者和16例非伤寒对照者小肠分泌物中抗伤寒杆菌脂多糖（LPS）和蛋白质抗原的抗体。作为一个群体，伤寒患者的小肠分泌物中抗LPS和抗蛋白质抗体明显高于对照组。这些抗体均为IgM和IgA类。血清中IgM或IgA抗体水平与小肠分泌物中的抗体水平之间无相关性。另一方面，在伤寒带菌者的小肠分泌物中，仅高水平存在抗伤寒杆菌LPS和蛋白质抗原的IgA类抗体。
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