Chandy K G, Stockley R A, Leonard R C, Crockson R A, Burnett D, MacLennan I C
Clin Exp Immunol. 1981 Dec;46(3):653-61.
The relative serum viscosity (RSV) at 37 degrees C was measured at presentation in all 179 patients with IgA myeloma admitted to the IIIrd and IVth British Medical Research Council trials until January 1981. An elevated relative serum viscosity (greater than 1.7) was noted in 83%. Hyperviscosity, as defined by a relative serum viscosity greater than 5, was a comparatively rare presenting feature (5.0%). The relationship between relative serum viscosity and IgA polymer equivalent concentration was examined in 33 of the 179 patients, selected to cover a wide range of serum viscosity. A significant correlation was observed between the two parameters (rs=0.7928, P less than 0.001). The sera from two patients with marked serum hyperviscosity (RSV=9.51 and 9.76) were clearly distinct from this relationship. Protein aggregation appeared to be a major determinant in the development of serum hyperviscosity in these two patients.
在1981年1月之前，对参加英国医学研究委员会第三和第四次试验的179例IgA骨髓瘤患者进行了入院时37摄氏度下的相对血清粘度（RSV）测量。83%的患者出现相对血清粘度升高（大于1.7）。相对血清粘度大于5定义的高粘度是一种相对罕见的临床表现（5.0%）。在179例患者中的33例中检查了相对血清粘度与IgA聚合物当量浓度之间的关系，这些患者的血清粘度范围很广。观察到这两个参数之间存在显著相关性（rs=0.7928，P<0.001）。两名血清高粘度明显的患者（RSV=9.51和9.76）的血清明显偏离这种关系。蛋白质聚集似乎是这两名患者血清高粘度发生的主要决定因素。
