Gallicchio V S, Murphy M J
Exp Hematol. 1981 Oct;9(9):938-44.
Recent work has led to conflicting results regarding the in vitro control of erythropoiesis in mice infected with Rauscher Leukemia Virus (RLV). Some reports claimed that marrow or splenic erythropoiesis from RLV-infected mice were independent of exogenously added erythropoietin (Ep), while other reports supported the view that erythroid stem cells (CFUE) from RLV-infected mice required EP for erythroid differentiation and proliferation. Results reported here demonstrate that erythroid differentiation and proliferation. Results reported here demonstrate that CFUE cultured from RLV-inoculated mice are dependent upon Ep for erythroid differentiation. Furthermore, RLV-infected mice which had received transfusions to suppress the endogenous production of Ep not only had a reduction in spleen weight and reticulocyte percentage, but also reduced numbers of CFUE and BFUE.
最近的研究工作在感染劳斯氏白血病病毒（RLV）的小鼠中红细胞生成的体外控制方面得出了相互矛盾的结果。一些报告称，来自RLV感染小鼠的骨髓或脾脏红细胞生成独立于外源性添加的促红细胞生成素（Ep），而其他报告则支持这样的观点，即来自RLV感染小鼠的红系干细胞（CFUE）需要Ep来进行红系分化和增殖。此处报告的结果表明了红系分化和增殖。此处报告的结果表明，从接种RLV的小鼠中培养的CFUE在红系分化方面依赖于Ep。此外，接受输血以抑制内源性Ep产生的RLV感染小鼠不仅脾脏重量和网织红细胞百分比降低，而且CFUE和BFUE的数量也减少。
