White M G, van Gelder J, Eastes G
J Clin Pharmacol. 1981 Nov-Dec;21(11):610-4. doi: 10.1002/j.1552-4604.1981.tb05672.x.
Bumetanide, ethacrynic acid, and furosemide were administered in two equipotent doses to the same five dogs in three separate studies. Intravascular volume was maintained by the replacement of urinary losses. Fractional chloride excretion was used as a marker of diuretic effect. Comparison of absolute and fractional excretion of Na+, Cl-, Ca2+, and Mg2+ did not demonstrate a significant difference among the three diuretics.
在三项独立研究中，分别以两种等效剂量对同五只犬施用布美他尼、依他尼酸和呋塞米。通过补充尿流失来维持血管内容量。氯排泄分数用作利尿效果的指标。对钠、氯、钙和镁的绝对排泄量和排泄分数进行比较，结果显示三种利尿剂之间无显著差异。
