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儿童肾血管性高血压外科治疗中的技术考量

Technical considerations in the surgical management of renovascular hypertension in children.

作者信息

Coran A G, Whitehouse W M, Stanley J C

出版信息

J Pediatr Surg. 1981 Dec;16(6):890-7. doi: 10.1016/s0022-3468(81)80842-1.

Abstract

Fifteen children with severe renovascular hypertension have been treated at the Mott Children's Hospital in the University of Michigan Medical Center between July 1974 and December 1980. The average age was 10.4 yr. Stenoses were of both intimal and medial fibrodysplastic types. Four patients had significant bilateral disease. Three patients had coexistent renal artery aneurysmal disease, and three others had midabdominal aortic coarctations. The most important diagnostic studies included assays of plasma renin activity and selective renal arteriography. Primary operations (11 unilateral, 4 bilateral) included 14 aortorenal by passes (13 vein grafts, 1 hypogastric artery graft), 1 vein patch angioplasty, 1 primary anastomosis, 1 aortic reimplantation, 1 partial nephrectomy (segmentectomy), and 1 arterial dilation. Four secondary operations were performed. Critical factors in pediatric reconstructive renovascular surgery include: (1) exposure through a generous transverse anterior abdominal incision, (2) systemic anticoagulation with sodium heparin, (3) end-to-end graft-to-renal artery anastomoses, (4) generous spatulation of vessels and grafts at anastomoses, (5) use of microvascular clamps, (6) use of silicon lubricants on dilators, and (7) extreme gentleness in handling all tissues. Eleven children experienced complete remission of hypertension. Four children were improved. Excellent results were attributable to carefully planned and executed reconstructive procedures.

摘要

1974年7月至1980年12月期间,密歇根大学医学中心莫特儿童医院对15例严重肾血管性高血压患儿进行了治疗。平均年龄为10.4岁。狭窄包括内膜和中膜纤维发育异常两种类型。4例患者有明显的双侧病变。3例患者并存肾动脉动脉瘤样病变,另外3例有腹主动脉中段缩窄。最重要的诊断性检查包括血浆肾素活性测定和选择性肾动脉造影。一期手术(11例单侧,4例双侧)包括14例主动脉 - 肾动脉搭桥术(13例采用静脉移植物,1例采用下腹动脉移植物)、1例静脉补片血管成形术、1例一期吻合术、1例主动脉再植入术、1例部分肾切除术(节段切除术)和1例动脉扩张术。进行了4例二期手术。小儿重建性肾血管手术的关键因素包括:(1)通过宽大的腹部横切口进行暴露;(2)用肝素钠进行全身抗凝;(3)移植物与肾动脉进行端端吻合;(4)在吻合处对血管和移植物进行充分的血管成形;(5)使用微血管夹;(6)在扩张器上使用硅润滑剂;(7)在处理所有组织时要极其轻柔。11例患儿高血压完全缓解。4例患儿病情有所改善。良好的结果归因于精心规划和实施的重建手术。

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