Stuckhardt J L, Brunden M N, Harris S B
J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):777-86. doi: 10.1080/15287398109530113.
The influence of intrauterine position on fetal body weight was statistically evaluated for 199 Dutch belted rabbit litters from does receiving various treatments during teratological studies. The data consisted of the number, type (live, dead, resorbed), and position of implantation sites in the left and right uterine horns. Body weights of live fetuses were also recorded. No statistically significant relation was found between the number of live, dead, or resorbed fetuses and intrauterine position. An effect related to differences in position between the left and right uterine horns for the proportions of largest fetuses was statistically significant. This uterine horn effect was not seen for the proportions of smallest fetuses. Positional differences within the uterine horns were significant and indicated a decrease in the proportion of largest fetuses and an increase in the proportion of smallest fetuses with increasing position number (ovarian to cervical end). Mean fetal weights differed significantly between the two uterine horns and among positions. There was a monotonic decrease in fetal weight with increasing position number. There were no significant associations between uterine horn or position and mean weight for the largest fetuses, but statistical evidence of the position effect was seen for weights of the smallest fetuses.
在致畸学研究中,对接受各种处理的母兔所产的199窝荷兰带兔仔进行了统计评估,以研究子宫内位置对胎儿体重的影响。数据包括植入部位在左右子宫角的数量、类型(活胎、死胎、吸收胎)和位置。还记录了活胎的体重。未发现活胎、死胎或吸收胎的数量与子宫内位置之间存在统计学上的显著关系。左右子宫角位置差异对最大胎儿比例的影响具有统计学意义。对于最小胎儿的比例,未观察到这种子宫角效应。子宫角内的位置差异显著,表明随着位置编号(从卵巢端到子宫颈端)增加,最大胎儿的比例下降,最小胎儿的比例增加。两个子宫角之间以及不同位置的平均胎儿体重存在显著差异。随着位置编号增加,胎儿体重呈单调下降。对于最大胎儿,子宫角或位置与平均体重之间没有显著关联,但对于最小胎儿的体重,有位置效应的统计证据。