Debons A F, Fani K, Jimenez F A
J Toxicol Environ Health. 1981 Nov-Dec;8(5-6):899-906. doi: 10.1080/15287398109530124.
The effect of aspirin on experimentally induced atherosclerosis was studied in rabbits. Rabbits were placed on an atherogenic diet containing either no aspirin or 0.2% aspirin supplement. Control rabbits were fed regular rabbit food or rabbit food supplemented with 0.2% aspirin. Ingestion of aspirin from the diets containing aspirin was equivalent to a daily dose of 100 mg/kg. As expected, 2 mo after the rabbits were placed on the atherogenic diet, extensive atheromatous lesions were observed on gross examination sporadically distributed along the walls of the aorta. The coronary arteries also exhibited atheromatous lesions on microscopic examination. Addition of aspirin to the atherogenic diet intensified the atherosclerosis as measured by proliferation of the intima of the aorta and coronary arteries and increased occurrence and distribution of atheromatous plaques. It is concluded that, under the conditions of this experiment, the addition of aspirin to an atherogenic diet greatly intensified atherogenesis.
研究了阿司匹林对实验性诱导家兔动脉粥样硬化的影响。将家兔置于含或不含阿司匹林补充剂（0.2%）的致动脉粥样化饮食中。对照家兔喂食常规兔粮或添加了0.2%阿司匹林的兔粮。从含阿司匹林的饮食中摄入的阿司匹林相当于每日剂量100mg/kg。正如预期的那样，在家兔开始食用致动脉粥样化饮食2个月后，大体检查发现主动脉壁上散在分布着广泛的动脉粥样硬化病变。显微镜检查显示冠状动脉也出现了动脉粥样硬化病变。通过主动脉和冠状动脉内膜增生以及动脉粥样斑块的发生率和分布增加来衡量，在致动脉粥样化饮食中添加阿司匹林会加剧动脉粥样硬化。得出的结论是，在本实验条件下，在致动脉粥样化饮食中添加阿司匹林会极大地加剧动脉粥样硬化的发生。
