格鲁米特类似物对离体大鼠肾上腺细胞类固醇生成的抑制作用。

Inhibition of steroidogenesis in isolated rat adrenal cells by glutethimide congeners.

作者信息

Aboul-Enein H Y, Holland S D

出版信息

Methods Find Exp Clin Pharmacol. 1980 Apr;2(2):71-6.

Abstract

A series of glutethimide congeners produce concentration-dependent inhibition of corticosterone production by a suspension of isolated rat adrenal cells. The dextro-rotatory antipode of aminoglutethimide is more potent than its levo enantiomer in inhibiting corticosterone production in this system. Glutethimide, its metabolite glutaconimide, and congeners including those with anti-convulsant activity, 4-hydroxyglutaconimide and 4-aminoglutethimide, have all demonstrated concentration-dependent inhibition of corticosterone production by isolated rat adrenal cells.

摘要

一系列氨鲁米特类似物可使分离的大鼠肾上腺细胞悬液对皮质酮的生成产生浓度依赖性抑制。在该系统中，氨鲁米特的右旋对映体在抑制皮质酮生成方面比其左旋对映体更有效。氨鲁米特、其代谢产物戊巴比妥以及包括具有抗惊厥活性的类似物4-羟基戊巴比妥和4-氨基氨鲁米特在内的类似物，均已证明可使分离的大鼠肾上腺细胞对皮质酮的生成产生浓度依赖性抑制。