Prophylaxis of metastases formation by prolonged non-specific immunostimulation associated with heparin therapy.

In rats with Ehrlich ascites tumors, prolonged non-specific immunostimulation with a polymicrobial preparation significantly reduced metastases. Prolonged anticoagulant therapy with heparin was also shown to reduce metastases. Combined prolonged therapy with both agents reduced metastases significantly more than therapy with either agent alone.