Ivanov V
Vet Med Nauki. 1981;18(8):6-11.
Studied were the rate and mechanism of glycogen breakdown in rats treated with Salmonella abortus ovis endotoxin. It was found that tissue homogenates from treated animals showed higher glycogenolytic activity in vitro as compared with homogenates from untreated animals, which demonstrated the direct mechanism of endotoxin action. The higher lytic activity with treated animals seemed to be associated with the higher activity of glycogen-phosphorylase, which showed peak values at the third hour following treatment. The higher activity of glycogen-phosphorylase was, in turn, the result of the enzyme reactivation under the effect of the endotoxin, and was not linked with the synthesis or new enzyme molecules.
研究了用羊流产沙门氏菌内毒素处理的大鼠体内糖原分解的速率和机制。结果发现，与未处理动物的匀浆相比，处理动物的组织匀浆在体外表现出更高的糖原分解活性，这证明了内毒素作用的直接机制。处理动物较高的分解活性似乎与糖原磷酸化酶的较高活性有关，糖原磷酸化酶在处理后第三小时达到峰值。糖原磷酸化酶的较高活性反过来又是内毒素作用下酶重新激活的结果，与新酶分子的合成无关。
