Oliva E A, Savino E A
Acta Biol Med Ger. 1981;40(9):1167-72.
When exposed to hypoxia, the spontaneously beating isolated atria from 24 h fasted rats exhibited a greater decline of their contraction frequency than those from fed rats. Furthermore, in a significant number of the fasted atria, hypoxia led to a complete cessation of pacemaker activity. Addition of insulin improved the performance of fed atria but was ineffective in the fasted atria. Lactate output, both in the presence or absence of added insulin was greater in the atria from fed rats. The extent of glycogen breakdown was similar in both groups of atria. It is suggested that these effects of fasting on pacemaker activity might at least partly have resulted from an inhibition of the glucose utilization under hypoxic conditions. Since fasted atria use faster their endogenous triglycerides, the present observations support the notion that fatty acids are detrimental to the heart during oxygen restriction.
在缺氧条件下，来自禁食24小时大鼠的自发搏动的离体心房，其收缩频率的下降幅度比来自喂食大鼠的离体心房更大。此外，在相当数量的禁食心房中，缺氧导致起搏活动完全停止。添加胰岛素可改善喂食心房的功能，但对禁食心房无效。无论是否添加胰岛素，喂食大鼠心房的乳酸产量都更高。两组心房中糖原分解的程度相似。提示禁食对起搏活动的这些影响可能至少部分是由于缺氧条件下葡萄糖利用受到抑制所致。由于禁食心房更快地利用其内源性甘油三酯，目前的观察结果支持脂肪酸在氧限制期间对心脏有害的观点。
