Hutchins G M, Haupt H M, Moore G W
Anat Rec. 1981 Dec;201(4):635-40. doi: 10.1002/ar.1092010407.
The development of the lung in 25 human embryos and early fetuses up to 140 mm crown-rump length was studied by examination of serial histologic sections, morphometry, and selected reconstructions. The proportion of pulmonary tissue consisting of tracheobronchial tree increases during this period. Bronchial cross-sectional diameter, length of the most distal bronchial branches, and thickness of the distal mesenchyme decline during development. The results are consistent with the concept that the dichotomous branching of the growing tracheobronchial tree occurs because of resistance to forward growth f the bronchial branch by compresses mesenchyme, pleura, or adjacent structures. Division and further growth of the bronchus takes place in areas of lower resistance. This process produces a "filling in" of space available for lung development and brings the epithelial and mesenchymal elements into their definitive relationships.
通过对连续组织学切片、形态测量学及选定的重建图像进行检查，研究了25例人类胚胎及头臀长至140毫米的早期胎儿肺的发育情况。在此期间，由气管支气管树构成的肺组织比例增加。发育过程中，支气管横截面积、最远端支气管分支的长度及远端间充质的厚度均减小。这些结果与以下概念一致：不断生长的气管支气管树的二分分支是由于受压的间充质、胸膜或相邻结构对支气管分支向前生长产生阻力所致。支气管的分支及进一步生长发生在阻力较低的区域。这一过程使得肺发育可用空间“填满”，并使上皮和间充质成分形成其最终关系。
