新生大鼠分离肝细胞中酮体生成与糖异生之间的关系。
Relationship between ketogenesis and gluconeogenesis in isolated hepatocytes from newborn rats.
作者信息
Ferré P, Satabin P, El Manoubi L, Callikan S, Girard J
出版信息
Biochem J. 1981 Nov 15;200(2):429-33. doi: 10.1042/bj2000429.
Abstract
In hepatocytes from 1-day-old rats, active gluconeogenesis occurs in parallel with active ketogenesis, although the carbon atoms of non-esterified fatty acids do not participate in glucose synthesis. Once a significant ketogenesis is established, a further increase does not enhance gluconeogenesis. Indeed, octanoate is more ketogenic than oleate, but stimulates gluconeogenesis to a similar extent.
摘要
在1日龄大鼠的肝细胞中，活跃的糖异生作用与活跃的生酮作用同时发生，尽管非酯化脂肪酸的碳原子不参与葡萄糖合成。一旦建立了显著的生酮作用，进一步增加并不会增强糖异生作用。实际上，辛酸比油酸的生酮作用更强，但对糖异生的刺激程度相似。
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