Motohashi N, Pruzansky S, Kawata T
J Craniofac Genet Dev Biol. 1981;1(1):73-94.
Roentgencephalometric investigation of four patients (three male, one female) with cerebral gigantism (Soto syndrome) demonstrated that both the neurocranium and facial skeleton are increased in size. The recessed flat facies characteristic of the syndrome can be attributed to the increased anterior cranial base length and frontal bossing combined with relative retroposition of the maxilla. Mandibular body length was increased but ramal height was within normal limits. The obtuse gonial angle added to the effective length of the mandible. The backward rotation of the mandible resulting from the obtuse gonial angle contributed to increased lower face height.
对4例（3例男性，1例女性）脑性巨人症（索托综合征）患者进行的X线头影测量研究表明，脑颅骨和面骨骼的大小均增大。该综合征典型的凹陷扁平面容可归因于前颅底长度增加、额部隆起，以及上颌骨相对后位。下颌体长增加，但下颌支高度在正常范围内。下颌角钝增加了下颌骨的有效长度。下颌角钝导致的下颌骨向后旋转致使下脸高度增加。
