猪外周血浆中13,14-二氢-15-酮前列腺素F2α的半衰期
Half-life of 13,14-dihydro-15-keto prostaglandin f2 alpha in peripheral plasma of the pig.
作者信息
Martin K A, Liptrap R M
出版信息
Res Vet Sci. 1981 Nov;31(3):387-9.
PMID:7342231
Abstract
The metabolite of prostaglandin F2 alpha (PGF2 alpha ) namely 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM), was administered as an intravenous bolus injection into five adult pigs. Concentrations of PGFM in blood collected periodically after injection indicated a biexponential decline suggesting a rapid distribution to the extracellular fluid and a slower elimination by metabolism. A mean half-life value of 14.97 +/- 1.33 (SD) minutes was calculated for the second component of the decline in PGFM concentration.
摘要
将前列腺素F2α（PGF2α）的代谢产物即13,14-二氢-15-酮-前列腺素F2α（PGFM）作为静脉推注注射到5只成年猪体内。注射后定期采集的血液中PGFM的浓度呈双指数下降，表明其迅速分布到细胞外液，并通过代谢缓慢消除。计算出PGFM浓度下降的第二个成分的平均半衰期值为14.97±1.33（标准差）分钟。
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