Feuer G
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):549-61.
During development from fetal to adult age in the female rat the rapid increase of hepatic drug metabolizing activity was paralleled by changes in the production of membrane bound phospholipids. Microsomal phosphatidylcholine synthesis was raised in particular, and was associated with an enhanced activity of S-adenosyl-L-methionine:microsomal phosphatidylethanolamine methyl transferase. This enzyme is responsible, in part, for phosphatidylcholine production by stepwise methylation. Phospholipid acyl components such as various unsaturated fatt acids also showed a sharp rise during development. These results demonstrated that maturation of the hepatic endoplasmic reticulum was correlated with an increased production of phosphatidylcholine that contained greater amounts of unsaturated fatty acids. It is therefore suggested that during maturation phospholipids are not only essential in providing the structural units of the membranes but they also act as organizers of enzyme function.
在雌性大鼠从胎儿期发育到成年期的过程中，肝脏药物代谢活性的快速增加与膜结合磷脂生成的变化同时出现。微粒体磷脂酰胆碱的合成尤其增加，并且与S-腺苷-L-甲硫氨酸：微粒体磷脂酰乙醇胺甲基转移酶活性增强相关。该酶部分负责通过逐步甲基化产生磷脂酰胆碱。磷脂酰基成分如各种不饱和脂肪酸在发育过程中也急剧增加。这些结果表明，肝脏内质网的成熟与含有更多不饱和脂肪酸的磷脂酰胆碱生成增加相关。因此有人提出，在成熟过程中，磷脂不仅在提供膜的结构单元方面至关重要，而且还作为酶功能的组织者发挥作用。
