Feuer G, Kardish R
Int J Clin Pharmacol Biopharm. 1975 Jun;11(4):366-74.
During pregnancy, a significant change has been found in the pattern of liver response to drugs. The activity of drug-metabolizing enzymes was inhibited due to the presence of increased amounts of reduced progesterone metabolites produced by the pregnant animal. Treatment of non-pregnant rats with 5alpha-pregnan-3beta-ol-20-one or 5alpha-pregnan-3beta,20beta-diol also caused a decreased drug hydroxylation. On the other hand, the administration of 16alpha-hydroxyprogesterone resulted in an increased activity. The contrasting effects of the different steroids on the function of the endoplasmic reticulum have shown correlation with changes in microsomal phospholipid synthesis. Reduced progesterone derivatives brought about a decrease, whereas hydroxyprogesterone an enhancement. The opposite actions provided evidence to postulate that during pregnancy the formation of endoplasmic reticulum and associated induction processes of drug metabolism might be regulated by a balance displayed in the production of various progesterone metabolites.
在怀孕期间，已发现肝脏对药物的反应模式有显著变化。由于怀孕动物产生的还原孕酮代谢物数量增加，药物代谢酶的活性受到抑制。用5α-孕烷-3β-醇-20-酮或5α-孕烷-3β,20β-二醇处理未怀孕的大鼠也会导致药物羟基化减少。另一方面，给予16α-羟基孕酮会导致活性增加。不同类固醇对内质网功能的相反作用已显示出与微粒体磷脂合成变化相关。还原孕酮衍生物导致减少，而羟基孕酮则导致增加。这些相反的作用为推测怀孕期间内质网的形成和药物代谢的相关诱导过程可能受各种孕酮代谢物产生中所表现出的平衡调节提供了证据。
