速尿对犬肠系膜血流量的影响。

Effect of furosemide on mesenteric blood flow in the dog.

作者信息

Gaffney G R, Day D K, Williamson H E

出版信息

Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):605-8.

Abstract

Diuretic therapy has been implicated as a possible inciting factor in nonocclusive mesenteric infarction. In view of this possibility, the effect of furosemide on superior mesenteric arterial blood flow (MBF) was investigated using electromagnetic flow probes in pentobarbital anesthetized dogs. After administration of furosemide, 1 mg/kg iv, MBF decreased by 44%. To assess the role of extracellular volume depletion induced by the diuresis in reducing MBF, volume depletion was prevented by infusing isotonic saline at a rate matching urine flow. In these experiments, MBF was not decreased by furosemide. Thus furosemide induces a marked decrease in mesenteric blood flow and this hemodynamic action involves a mechanism that is dependent upon the volume depletion induced by the drug.

摘要

利尿疗法被认为可能是导致非闭塞性肠系膜梗死的一个诱发因素。鉴于这种可能性，在戊巴比妥麻醉的犬身上，使用电磁血流探头研究了呋塞米对肠系膜上动脉血流量（MBF）的影响。静脉注射1mg/kg呋塞米后，MBF下降了44%。为了评估利尿引起的细胞外液量减少在降低MBF中的作用，通过以与尿流相匹配的速率输注等渗盐水来防止体液减少。在这些实验中，呋塞米并未使MBF降低。因此，呋塞米可导致肠系膜血流量显著下降，这种血流动力学作用涉及一种依赖于该药物引起的体液减少的机制。