Srivastava A K, Singh N N
Acta Pharmacol Toxicol (Copenh). 1981 Oct;49(4):266-9. doi: 10.1111/j.1600-0773.1981.tb00904.x.
Exposure of the Indian catfish (Heteropneustes fossilis) to a sublethal concentration of 0.14 p.p.m. aldrin for 3, 6, 12, 48, and 96 hrs affected carbohydrate metabolism. Muscle glycogenolysis and glycogenesis were obtained at 3 and 12 hrs, respectively. Hepatic glycogenolysis occurred at 3, 48, and 96 hrs. The treatment caused hyperglycaemia at 3, 6, 48, and 96 hrs, and hypoglycaemia at 12 hrs. Blood pyruvate values increased significantly at 3, 6, and 96 hrs. Hyperlacticaemia was observed at 3 and 12 hrs but hypolacticaemia developed at 96 hrs. The results are discussed in relation to acute stress syndrome. Also, impairment of carbohydrate metabolism by aldrin may be involved in the biochemical mechanism for its toxic action. It is concluded that evaluation of carbohydrate metabolites in fish could prove useful as a rapid method for assessing acute toxicity of pesticides.
将印度鲶鱼（Heteropneustes fossilis）暴露于0.14 ppm艾氏剂的亚致死浓度下3、6、12、48和96小时，会影响碳水化合物代谢。肌肉糖原分解和糖原合成分别在3小时和12小时出现。肝脏糖原分解发生在3、48和96小时。该处理在3、6、48和96小时导致高血糖，在12小时导致低血糖。血液丙酮酸值在3、6和96小时显著升高。在3小时和12小时观察到高乳酸血症，但在96小时出现低乳酸血症。结合急性应激综合征对结果进行了讨论。此外，艾氏剂对碳水化合物代谢的损害可能涉及其毒性作用的生化机制。得出的结论是，评估鱼类中的碳水化合物代谢产物可能被证明是一种评估农药急性毒性的快速方法。
