[瓜德罗普岛（法属西印度群岛）献血者血红蛋白病的系统筛查]
[Systematic screening of hemoglobinopathies in blood donors in Guadeloupe (French West Indies)].
作者信息
Fabritius H, Millan J, Le Corroller Y
出版信息
Rev Fr Transfus Immunohematol. 1978 Sep;21(4):937-50. doi: 10.1016/s0338-4535(78)80051-8.
We report the results of a systematic survey carried on 8.961 healthy Guadeloupean blood donors, where we looked for hemoglobinopathies. The results are expressed in regard of the race and site of living (urban or rural) of the subjects. Of these 8.961 subjects, aged 18 to 60, 7.75% were sickle cell trait carriers, 2.36% were heterozygous for Hb C and 0,2% had a significant elevation of Hb F. Were also report some less frequent phenotypes : three Hb AD, five Hb SC, one Hb CC, two Hb SF, one Hb CF and one case of isolated Hb, A2 elevation. Two rare hemoglobinopathies are reported: a case of Hb Korle Bu associated with Hb S an a case of Hb N-Baltimore. Our datas regarding race and sex of Hb S and Hb C carriers are evaluated. These results are compared to previous studies carried on healthy blood donors in Guadeloups. Problems related to the detection of hemoglobin abnormalities in a blood transfusion center are reviewed.
我们报告了对8961名瓜德罗普健康献血者进行的一项系统调查结果，在这些献血者中我们筛查了血红蛋白病。结果按照受试者的种族和居住地点（城市或农村）进行表述。在这8961名年龄在18至60岁的受试者中，7.75%为镰状细胞性状携带者，2.36%为Hb C杂合子，0.2%的Hb F显著升高。我们还报告了一些较罕见的表型：3例Hb AD、5例Hb SC、1例Hb CC、2例Hb SF、1例Hb CF以及1例单纯Hb A2升高的病例。报告了两例罕见的血红蛋白病：1例与Hb S相关的Hb Korle Bu病例和1例Hb N - 巴尔的摩病例。我们评估了关于Hb S和Hb C携带者的种族和性别的数据。将这些结果与之前在瓜德罗普对健康献血者进行的研究进行了比较。回顾了与输血中心血红蛋白异常检测相关的问题。
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