Paulin R, Piquet J, Seck S, Ndiaye M
Bull Soc Pathol Exot Filiales. 1981 Nov-Dec;74(6):649-58.
The both purposes of our investigation were to determine initially the level of total serum IgE in various parasitic infections and the variations of this level after the initiation of specific treatment. In the study, III sera from black race patients with a clinical and biological diagnosis of helmintic or protozoal infections and without allergic diseases were tested by the commercially available "Radioimmunosorbent test" (Pharmacia Laboratories). In helmintic infections: the IgE concentration was higher than normal level: --in 100% of patients infested with ankylostoma, trichocephalus (mean concentration m: 2,961 UI/ml) or schistosoma (m: 1,578 UI/ml); --in 70% of patients infested with ascaris (m: 1,110 UI/ml). In protozoal infections: the abnormal IGE level was found only in 44% and 14% of cases respectively of malaria (m = 704 UI/ml) and of leishmaniasis (441 UI/ml). The time course of total serum IgE determined after the treatment initiation showed that: a) in patients with intracellular helminthiasis and protozoal infections serum IgE concentrations were gradually increased in a statistically highly significant way; b) in cases with intestinal helminthiasis, high levels disappeared ane returned rapidly to normal values.
我们研究的两个目的，首先是确定各种寄生虫感染患者血清总IgE水平，以及开始特异性治疗后该水平的变化。在这项研究中，我们采用市售的“放射免疫吸附试验”（Pharmacia实验室），对113例经临床和生物学诊断为蠕虫或原生动物感染且无过敏性疾病的黑人患者的血清进行了检测。在蠕虫感染中：IgE浓度高于正常水平：——在100%感染钩虫、鞭虫（平均浓度m：2961 UI/ml）或血吸虫（m：1578 UI/ml）的患者中；——在70%感染蛔虫（m：1110 UI/ml）的患者中。在原生动物感染中：仅在44%的疟疾患者（m = 704 UI/ml）和14%的利什曼病患者（441 UI/ml）中发现异常IgE水平。开始治疗后测定的血清总IgE时间进程表明：a）在细胞内蠕虫病和原生动物感染患者中，血清IgE浓度以统计学上高度显著的方式逐渐升高；b）在肠道蠕虫病病例中，高水平消失并迅速恢复到正常值。
