Welt K, Schippel G, Schippel K, Scheller W
Gegenbaurs Morphol Jahrb. 1981;127(5):629-35.
After intravenous or intracardial application of horseradish peroxidase (HRP) at the myocardial capillaries of fetal, juvenile and adult rats a fast transport of the tracer into the interstite can be observed. In the fetal cases the transport takes place especially through the interendothelial junctions, in the postnatal cases a considerably amount of the peroxidase traversed also by plasmalemmal vesicles. In adults the T-tubules of the myocytes are labelled already after 15 min of circulation. From fetal stages up to adults the junctions of the endocardium are well permeable to HRP. After a short circulation time we found large deposits of reaction product in the subendocardial space. The reasons for the different permeability of fetal heart and skeletal muscle capillaries were discussed.
在对胎儿、幼年和成年大鼠的心肌毛细血管进行静脉内或心内注射辣根过氧化物酶（HRP）后，可以观察到示踪剂快速转运到间质中。在胎儿的情况下，转运尤其通过内皮细胞间连接进行；在出生后的情况下，相当数量的过氧化物酶也通过质膜小泡穿过。在成年大鼠中，心肌细胞的T小管在循环15分钟后就已被标记。从胎儿期到成年期，心内膜的连接对HRP具有良好的通透性。在短循环时间后，我们在内皮下间隙发现了大量反应产物沉积。文中讨论了胎儿心脏和骨骼肌毛细血管通透性不同的原因。
