Arora R G, Frölén H
Acta Vet Scand. 1981;22(3-4):535-52. doi: 10.1186/BF03548678.
Ochratoxin A was dissolved in corn oil and administered by stomach tube to pregnant CBA mice in varying dosages. On gestation day 8 or 9 the dams were treated with a dose of either 1, 2 or 4 mg/kg body weight and on 1 of various other days (2, 4, 6–7, 10–14, 16) or 2 days prior to conception they were supplied with a dose of 4 mg/kg. The highest amount of the toxin given on day 7, 8 or 9 decreased the prenatal survival and on day 9 diminished the foetal growth. A marked impairment in foetal growth also resulted from treatment before conception. Overt craniofacial anomalies were produced only by exposure on day 8 or 9 and their incidence, multiplicity and severity increased with increasing dosage, the peak effect being on day 9. A study of the anatomical features of the craniofacial skeleton disclosed the failure of closure of neurocranium and an abnormal configuration, position and size of the bones of the base and lateral walls of the skull.
赭曲霉毒素A溶解于玉米油中，通过胃管以不同剂量给予怀孕的CBA小鼠。在妊娠第8天或第9天，母鼠接受1、2或4毫克/千克体重的剂量处理，在其他不同日期（第2、4、6 - 7、10 - 14、16天）中的某一天，或在受孕前2天，它们接受4毫克/千克的剂量。在第7、8或9天给予的最高毒素量降低了产前存活率，在第9天减少了胎儿生长。受孕前的处理也导致胎儿生长明显受损。只有在第8天或第9天接触才会产生明显的颅面异常，其发生率、多发性和严重程度随剂量增加而增加，第9天效应达到峰值。对颅面骨骼解剖特征的研究揭示了神经颅闭合失败以及颅骨底部和侧壁骨骼的异常形态、位置和大小。
