Enhancement of spiramycin concentration by bromhexin in the bovine nasal secretions.

Intramuscular injection of bromhexin (Quentan) results in increased bioavailability of spiramycin in nasal secretions. In the presence of a mucolytic agent, the area under the curve calculated according to spiramycin concentrations found in nasal secretions increases by 6%, 41% and 32% respectively in the course of three days of treatment. This potentiation reveals the interest involved in administering a combination of bromhexine and antibiotics in the treatment of infectious diseases of the respiratory tract.