Wilson D J, Lewis R C, Vidt D G
Cardiovasc Clin. 1981;12(2):79-91.
Immediate or rapid reduction in blood pressure may be indicated in the management of hypertensive emergencies in patients with recognized cardiovascular or cerebrovascular disease. Our study has shown that pulse administration of diazoxide is effective in reducing blood pressure in these patients with severe, uncontrolled hypertension. Blood pressure reduction was gradual and could be titrated with repeated pulses of 50 or 75 mg of diazoxide. Pulse administration of diazoxide may represent the preferred method of administration in most patients when this potent antipressor agent is indicated. Our experience suggests that pulse diazoxide appears to be a suitable alternative to other parenteral antihypertensive agents and provides a gradual reduction of blood pressure in high-risk patients with severe, uncontrolled hypertension. The procedure carries a minimum risk of serious cardiovascular sequelae.
对于已确诊心血管或脑血管疾病的患者，在高血压急症的治疗中可能需要立即或快速降低血压。我们的研究表明，静脉推注二氮嗪对这些严重、血压控制不佳的患者有效降低血压。血压下降是渐进性的，可通过重复推注50或75毫克二氮嗪进行滴定。当需要使用这种强效抗高血压药物时，静脉推注二氮嗪可能是大多数患者的首选给药方法。我们的经验表明，静脉推注二氮嗪似乎是其他胃肠外抗高血压药物的合适替代方法，可使严重、血压控制不佳的高危患者血压逐渐降低。该操作发生严重心血管后遗症的风险极小。
