Fountain M W, Ganjam V K, Ravis W M, Pedersoli W D
Drug Chem Toxicol. 1981;4(4):353-61. doi: 10.3109/01480548109017826.
The effect of concomitant administration in normal dogs of phenobarbital with either oral free digoxin, oral liposome-entrapped digoxin were examined. Phenobarbital induced a transient rise in serum digoxin concentrations during concomitant administration of oral free digoxin. Phenobarbital did not affect serum concentrations of either oral or intravenous liposome-entrapped digoxin. The results suggest that liposome-entrapped digoxin may be protected against transient fluctuations in serum concentrations during concomitant administration of phenobarbital. The protective liposome encapsulation of digoxin may prevent digoxin toxicosis in dogs induced by elevations in serum digoxin concentrations during concomitant administration of phenobarbital.
研究了苯巴比妥与口服游离地高辛或口服脂质体包裹地高辛同时给药对正常犬的影响。在与口服游离地高辛同时给药期间，苯巴比妥可导致血清地高辛浓度短暂升高。苯巴比妥不影响口服或静脉注射脂质体包裹地高辛的血清浓度。结果表明，脂质体包裹地高辛在与苯巴比妥同时给药期间，可能免受血清浓度的短暂波动影响。地高辛的保护性脂质体包封可能预防犬在与苯巴比妥同时给药期间因血清地高辛浓度升高而诱发的地高辛中毒。
