Tumorigenesis with 1,1-diallylhydrazine in mice.

1,1-Diallylhydrazine was administered as a 0.03125% solution in drinking water for life to Swiss mice, from 6 weeks of age. Compared to untreated controls, in treated animals the lung tumor incidence rose from 25 to 76% in females and from 26 to 76% in males, whereas the incidence of forestomach tumors increased from 4 to 14% in females and from 0 to 34% in males. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs and squamous cell papillomas and carcinomas of the forestomach. This work is part of our structure activity inquiry and demonstrates the relative carcinogenic potency of another disubstituted allylhydrazine.