Naha P M
Anticancer Res. 1981;1(5):275-7.
Cytotoxicity of L-canavanive, a structural analogue of L-arginine, was tested by means of (1) inhibition of DNA synthesis in Balb/c-3T3 cell line and (2) inhibition of mitosis in peripheral blood lymphocytes in culture. The cytostatic nature of inhibition caused by L-canavanine was indicated by the complete recovery of cells after withdrawal of the drug.
通过以下两种方式检测了L-精氨酸的结构类似物L-刀豆氨酸的细胞毒性：（1）抑制Balb/c-3T3细胞系中的DNA合成；（2）抑制培养的外周血淋巴细胞中的有丝分裂。停药后细胞完全恢复，表明L-刀豆氨酸引起的抑制具有细胞生长抑制特性。
