Zumoff B, O'Connor J, Levin J, Markham M, Strain G W, Fukushima D K
Anticancer Res. 1981;1(5):287-91.
24-hour mean plasma levels of T3 and T4 were compared in 29 rigorously selected breast cancer patients (all stages) and 27 healthy women, and 8 A.M. "spot" plasma T4 levels were compared in 43 consecutive unselected breast cancer patients (all stages), 22 women with other-than-breast cancer, 21 women with miscellaneous non-cancerous illnesses, and the same 27 healthy women. The 24-hour T3 levels were the same in the breast cancer patients and healthy controls, but the 24-hour T4 levels were significantly higher in the cancer patients (7.7 vs 5.8 micrograms/dl, p less than 0.001); equal elevations were present in all stages of cancer. Spot T4 levels were likewise significantly higher in the breast cancer patients than in the healthy controls (8.8 vs 7.3 micrograms/dl, p less than 0.005). The women with other-than-breast cancer and the women with miscellaneous non-cancerous illnesses also showed significant elevations of spot T4 levels, indistinguishable from those of the breast cancer patients. It is concluded that breast cancer patients as a group show significant hyperthyroxinemia and that this finding may represent a second nonspecific abnormality of thyroid hormones in disease, hypotriiodothyroninemia (low-T3 syndrome) being the first.
对29名经过严格挑选的各期乳腺癌患者和27名健康女性的24小时平均血浆T3和T4水平进行了比较，并对43名未经挑选的连续各期乳腺癌患者、22名非乳腺癌女性、21名患有其他非癌性疾病的女性以及同样的27名健康女性的上午8点“即时”血浆T4水平进行了比较。乳腺癌患者和健康对照组的24小时T3水平相同，但癌症患者的24小时T4水平显著更高（7.7微克/分升对5.8微克/分升，p<0.001）；癌症各期均有同等程度的升高。乳腺癌患者的即时T4水平同样显著高于健康对照组（8.8微克/分升对7.3微克/分升，p<0.005）。非乳腺癌女性和患有其他非癌性疾病的女性的即时T4水平也显著升高，与乳腺癌患者的水平无差异。结论是，乳腺癌患者作为一个群体表现出显著的甲状腺素血症，这一发现可能代表了疾病中甲状腺激素的第二种非特异性异常，第一种是低三碘甲状腺原氨酸血症（低T3综合征）。
