Damon M, Godard P, Chaintreuil J, Flandre O, Michel F B, Crastes de Paulet A
Biomedicine. 1981 Dec;35(7-8):224-7.
Alveolar macrophages (AM) form the first line of defense against aggression in the lungs. The goal of the present study was to evaluate AM phagocytic function in two types of asthmatic patients: allergic asthma (14 patients) and asthma following ingestion of aspirin (6 patients). Macrophages obtained from bronchiolo-alveolar washings were isolated as a result of their adherence to glass and cultured for 24 hours. The results show that AM viability and phagocytosis of zymosan are reduced in the asthmatic patient. Decreased viability in patients sensitive to aspirin may be the result of alveolar eosinophilia, a quasiconstant finding in asthmatics. Although impaired phagocytosis of zymosan may be explained by the presence of surface IgE on AM of the allergic asthma patient, this is not the case for the aspirin sensitive patient.
肺泡巨噬细胞（AM）构成了肺部抵御侵袭的第一道防线。本研究的目的是评估两种类型哮喘患者的AM吞噬功能：过敏性哮喘（14例患者）和摄入阿司匹林后引发的哮喘（6例患者）。通过支气管肺泡灌洗获得的巨噬细胞因其对玻璃的黏附性而被分离出来，并培养24小时。结果显示，哮喘患者的AM活力和酵母聚糖吞噬作用降低。对阿司匹林敏感患者的活力降低可能是肺泡嗜酸性粒细胞增多的结果，这在哮喘患者中是一个近乎恒定的发现。虽然过敏性哮喘患者的AM表面存在IgE可能解释酵母聚糖吞噬作用受损，但阿司匹林敏感患者并非如此。
