Nolibe D, Berel E, Masse R, Lafuma J
Biomedicine. 1981 Dec;35(7-8):230-4.
A high level of antitumoral cytotoxicity was observed in the lymphoid population extracted by perfusion from lung capillaries. The in vitro cytotoxicity against tumor cells was demonstrated with the murine lymphoma YAC-1 cells or with the syngeneic P 77 rat lung fibrohistiocytoma cells. It was demonstrated that this cytotoxic activity had the characteristics of natural killer activity. At the same effector to target ratio the efficiency of this population was higher than in blood or spleen. Since the total number of lymphoid cells arrested in the capillary of the lungs is very high the lungs seemed an immunologically privileged site. A close relationship was observed between this activity in vitro and the rapid elimination in vivo of same tumor cells trapped in lungs (more than 99% after 24 hours).
在通过肺毛细血管灌注提取的淋巴细胞群体中观察到高水平的抗肿瘤细胞毒性。用小鼠淋巴瘤YAC-1细胞或同基因P 77大鼠肺纤维组织细胞瘤细胞证明了其对肿瘤细胞的体外细胞毒性。结果表明，这种细胞毒性活性具有自然杀伤活性的特征。在相同的效应细胞与靶细胞比例下，该群体的效率高于血液或脾脏中的效率。由于滞留在肺毛细血管中的淋巴细胞总数非常高，肺似乎是一个免疫特惠部位。观察到这种体外活性与体内快速清除滞留在肺中的相同肿瘤细胞之间存在密切关系（24小时后超过99%）。
