[Acylated tripeptides as chemotaxin antagonists (author's transl)].

Boc-protected peptides antagonise leucocyte chemotaxis induced by formylated derivatives. Other protecting groups similar to Boc were investigated to see if they also produce chemotaxin antagonists when combined with the chemotactic standard sequence' Met-Leu-Phe. Four related acylated tripeptides were synthesized and studied in the agarose test. It could be proved that they influence the chemotaxin HCO-Met-Leu-Phe-OH as potent antagonists.