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Distribution and metabolic fate in mammals of the potent convulsant and GABA antagonist t-butyl-bicyclophosphate and its methyl analog.

作者信息

Milbrath D S, Eto M, Casida J E

出版信息

Toxicol Appl Pharmacol. 1978 Nov;46(2):411-20. doi: 10.1016/0041-008x(78)90086-8.

DOI:10.1016/0041-008x(78)90086-8
PMID:734670
Abstract
摘要

相似文献

1
Distribution and metabolic fate in mammals of the potent convulsant and GABA antagonist t-butyl-bicyclophosphate and its methyl analog.
Toxicol Appl Pharmacol. 1978 Nov;46(2):411-20. doi: 10.1016/0041-008x(78)90086-8.
2
Probicyclophosphates: monocyclophosphates as potential prodrugs for bicyclophosphate GABA antagonists.
Toxicol Appl Pharmacol. 1985 Oct;81(1):50-7. doi: 10.1016/0041-008x(85)90119-x.
3
Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor.惊厥性和抗惊厥性γ-丁内酯与印防己毒素/T-丁基双环磷硫酯(TBPS)受体结合。
Biochem Pharmacol. 1985 Dec 1;34(23):4187-90. doi: 10.1016/0006-2952(85)90218-7.
4
Bicycloorthocarboxylate convulsants. Potent GABAA receptor antagonists.双环邻羧酸酯类惊厥剂。强效γ-氨基丁酸A受体拮抗剂。
Mol Pharmacol. 1985 Sep;28(3):246-53.
5
GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system.GABAA受体亚型:大鼠中枢神经系统中GABA、苯二氮䓬和惊厥剂结合位点的放射自显影比较
J Chem Neuroanat. 1990 Jan-Feb;3(1):59-76.
6
t-Butyl bicyclo phosphate: a convulsant and GABA antagonist more potent than bicuculline [proceedings].叔丁基双环磷酸酯:一种惊厥剂和GABA拮抗剂,比荷包牡丹碱更有效[会议论文集]
Br J Pharmacol. 1977 Jun;60(2):275P-276P.
7
The effect of CNS depressants on GABA receptor chloride ionophore complexes.
Acta Pharm Hung. 1989 Jul;59(4):173-7.
8
Effect of benzodiazepine binding site ligands on [35S] t-butylbicyclophosphorothionate ([35S]TBPS) binding to rat brain: an autoradiographic study.苯二氮䓬结合位点配体对[35S]叔丁基双环磷硫代酸盐([35S]TBPS)与大鼠脑结合的影响:一项放射自显影研究。
Adv Biochem Psychopharmacol. 1986;41:227-38.
9
Solubilization of convulsant/barbiturate binding activity on the gamma-aminobutyric acid/benzodiazepine receptor complex.
Biochem Biophys Res Commun. 1984 Mar 15;119(2):530-6. doi: 10.1016/s0006-291x(84)80280-6.
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2,6,7-Trioxabicyclo[2.2.2]octanes: chemistry, toxicology and action at the GABA-gated chloride channel.
Adv Biochem Psychopharmacol. 1988;45:109-23.

引用本文的文献

1
Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloalkane and pyrethroid insecticides with the brain-specific t-butylbicyclophosphorothionate receptor.双环磷酯与某些多氯环烷和拟除虫菊酯类杀虫剂与脑特异性叔丁基双环硫代磷酸酯受体相互作用的构效关系。
Environ Health Perspect. 1985 Sep;61:123-32. doi: 10.1289/ehp.8561123.