Linday L A, Levin A R, Klein A A, Reidenberg M M, Engle M A
Pediatr Pharmacol (New York). 1981;1(4):267-78.
Based on the favorable experience with vasodilator therapy in adult heart disease and the results of acute dogs experiments, we undertook the hemodynamic evaluation of hydralazine and phentolamine during diagnostic cardiac catheterization. We studied seven infants and children with left-to-right (leads to R) shunts at atrial, ventricular, or ductal levels to determine whether vasodilator therapy might be useful in the treatment of infants with congestive heart failure (CHF) due to large L leads to R shunts. Shunts, flows, and resistances were measured by the indicator dilution and Fick techniques before and after administration of the drug. At a dose sufficient to produce an effect, the shunt flow increased after each drug. There is no evidence from studies at cardiac catheterization of therapeutic efficacy for vasodilators in the treatment of CHF due to cardiac L leads to R shunts.
基于血管扩张剂疗法在成人心脏病治疗中的良好经验以及急性犬实验结果，我们在诊断性心导管检查期间对肼屈嗪和酚妥拉明进行了血流动力学评估。我们研究了7例在心房、心室或动脉导管水平存在左向右分流的婴幼儿，以确定血管扩张剂疗法对于治疗因大量左向右分流导致充血性心力衰竭（CHF）的婴幼儿是否有用。在给药前后，通过指示剂稀释法和菲克技术测量分流、血流量和阻力。在足以产生效果的剂量下，每种药物给药后分流血流量均增加。心导管检查研究没有证据表明血管扩张剂对治疗因心脏左向右分流导致的CHF具有治疗效果。
