Due C, Ebbesen P
Anticancer Res. 1981;1(2):87-8.
A 30,000-50,000 MW extract of mouse skin beta-irradiated 3 months previously with 3,000 rads, exerted a stronger in vivo inhibitory effect on mitoses in the basal layer of normal skin than a similar extract from unirradiated skin. Furthermore, epidermis beta-irradiated 3 months previously showed a reduced mitotic rate and a decreased susceptibility to inhibition by the 30-50,000 MW extract. The pathogenesis of the long term effect of irradiation might include interference with the functioning of a local mitotic inhibitor.
三个月前接受3000拉德β射线照射的小鼠皮肤的30000 - 50000分子量提取物，比未照射皮肤的类似提取物对正常皮肤基底层有更强的体内有丝分裂抑制作用。此外，三个月前接受β射线照射的表皮有丝分裂率降低，对30000 - 50000分子量提取物抑制作用的敏感性也降低。辐射长期效应的发病机制可能包括干扰局部有丝分裂抑制剂的功能。
