Yates R S, Osterholm R K
J Clin Gastroenterol. 1980 Dec;2(4):359-63. doi: 10.1097/00004836-198012000-00008.
The hemolytic-uremic syndrome has varied prodromal symptoms. In a few patients the dominant initial gastrointestinal symptoms have led to a presumptive diagnosis of ulcerative colitis. The colitis tends to be self-limited, to have minimal lesions detected by proctoscopic or roentgenographic studies, and usually to resolve spontaneous without specific therapy. Rarely, more serious colonic involvement can progress to toxic megacolon, rectal prolapse, colonic perforation, intussusception, or colonic stricture. Early hemodialysis will reduce morbidity and mortality in patients with severe renal impairment. The physician should be aware of this entity when young patients present with a picture compatible with ulcerative colitis in order to circumvent delayed or inappropriate management of what would appear to be a primary bowel disorder.
溶血尿毒综合征有多种前驱症状。少数患者以占主导的初始胃肠道症状为主，导致初步诊断为溃疡性结肠炎。这种结肠炎往往是自限性的，通过直肠镜或X线检查发现的病变极少，通常无需特殊治疗即可自行缓解。极少数情况下，更严重的结肠受累可进展为中毒性巨结肠、直肠脱垂、结肠穿孔、肠套叠或结肠狭窄。早期血液透析可降低严重肾功能损害患者的发病率和死亡率。当年轻患者出现与溃疡性结肠炎相符的症状时，医生应了解这种疾病，以免对看似原发性肠道疾病的患者进行延迟或不恰当的治疗。
