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中心粒的几何设计是否暗示了它们的功能?

Does the geometric design of centrioles imply their function?

作者信息

Albrecht-Buehler G

出版信息

Cell Motil. 1981;1(2):237-45. doi: 10.1002/cm.970010206.

Abstract

The paper suggests several principles of construction of a microscopically small device for locating the directions of signal sources in microscopic dimensions. It appears that the simplest and smallest device that is compatible with the scrambling influence of thermal fluctuations as are demonstrated by Brownian motion is a pair of cylinders oriented at right angles to each other. Nine equally spaced blades run in a pitched fashion along the mantle of each cylinder. The blades have a concave cross-section and bend around the circumference of the cylinder in a certain rotational pattern. Considering the striking similarity of this hypothetical device with centrioles, the paper puts forward the conjecture that centrioles locate the direction of hypothetical signals inside cells.

摘要

该论文提出了一种用于在微观尺度上定位信号源方向的微观小型装置的构建原则。似乎与布朗运动所证明的热涨落的扰动向兼容的最简单、最小的装置是一对相互成直角定向的圆柱体。九个等间距的叶片以倾斜的方式沿着每个圆柱体的外壳运行。叶片具有凹形横截面,并以一定的旋转模式围绕圆柱体的圆周弯曲。考虑到这个假设装置与中心粒的惊人相似性,该论文提出了一个猜想,即中心粒在细胞内定位假设信号的方向。

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