Konys J, Mackiewicz U, Drygas J
Arch Immunol Ther Exp (Warsz). 1981;29(6):783-8.
A single dose of 300 mg of cyclophosphamide was injected intraperitoneally (i.p.). During the highest cyclophosphamide-induced elimination of lymphocytes from the spleen and lymph node, sheep red blood cells (SRBC) were injected either intravenously (i.v.) in a dose of 4 X 10(8) or into the hind foot-pads in a dose of 2 X 10(8). At consecutive days after cyclophosphamide administration, the number of cells producing 19S and 7S antibodies in the spleen and lymph node as well as antibody titer in the serum were determined. As observed, cyclophosphamide-induced depletion of the lymphoid tissue did not change the kinetics of appearance of cells producing antibodies in the spleen and lymph node but only diminished their number as well as the titer of antibodies in the serum.
腹腔注射（i.p.）300毫克环磷酰胺单剂量。在环磷酰胺诱导脾脏和淋巴结淋巴细胞消除最严重期间，以4×10⁸的剂量静脉注射（i.v.）绵羊红细胞（SRBC），或以2×10⁸的剂量注射到后足垫。在给予环磷酰胺后的连续几天，测定脾脏和淋巴结中产生19S和7S抗体的细胞数量以及血清中的抗体滴度。如观察到的，环磷酰胺诱导的淋巴组织耗竭并未改变脾脏和淋巴结中产生抗体细胞出现的动力学，只是减少了它们的数量以及血清中抗体的滴度。
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