Zabłocki B, Kierońska D, Marczyk B, Rózalska B, Lauk-Puchała B
Arch Immunol Ther Exp (Warsz). 1981;29(6):805-11.
The influence of 6-metoxy-cumaranon-2-acetic acid and its four derivatives on the humoral and cellular immunogenesis was determined. The study of immunosuppressive properties included: the control of the level of peripheral blood lymphocytes, the estimation of transplantation immunity, GvH reaction, PFC production for SRBC and LPS and the determination of the number of cells possessing receptors for antigen, Fc fragment and complement. Furthermore, blast transformation of lymphocytes stimulated with PHA was estimated as well as the cytotoxic effect of sensitized lymphocytes. The results indicate immunosuppressive activity of acetamides HKCMF and HKCHF. They lowered the level of circulating lymphocytes, the number of cells possessing receptors for complement and they hindered PFC production for SRBC and LPS. Moreover, acetamide HKCHF weakened the cytotoxic activity of lymphocytes sensitized to alloantigens.
测定了6-甲氧基香豆满酮-2-乙酸及其四种衍生物对体液免疫和细胞免疫发生的影响。对免疫抑制特性的研究包括：对外周血淋巴细胞水平的控制、移植免疫的评估、移植物抗宿主反应、对绵羊红细胞和脂多糖的空斑形成细胞产生情况的测定，以及对抗原、Fc片段和补体具有受体的细胞数量的测定。此外，还评估了用植物血凝素刺激的淋巴细胞的母细胞转化情况以及致敏淋巴细胞的细胞毒性作用。结果表明乙酰胺HKCMF和HKCHF具有免疫抑制活性。它们降低了循环淋巴细胞的水平、具有补体受体的细胞数量，并阻碍了对绵羊红细胞和脂多糖的空斑形成细胞的产生。此外，乙酰胺HKCHF削弱了对同种异体抗原致敏的淋巴细胞的细胞毒性活性。
