Morat M, Locatelli A, Terqui M, Chevalier M, Chambon M, Dufaure J P
Reprod Nutr Dev (1980). 1980;20(1A):61-76.
Hypophysectomy of the boar resulted in a rapid drop in plasma testosterone level. hCG injections (400 IU/day) considerably elevated testosteronemia (up to 16.41 ng/ml). This effect was obtained either in the days following the operation or several months after (up to 134 days). In the latter case, the effect was temporary because the testosterone level dropped again after 15 days of injections. The sexual target organs (epididymis, seminal vesicle, prostate and Cowper glands) underwent structural change which, in the epithelium, corresponded to fluctuations in testosterone level. These effects were less marked in the cauda epididymis than in other target tissues. In various target organs, the conjunctivomuscular stroma developed after the operation; it did not regress at all, or incompletely, when the epithelia were stimulated indirectly by hCG, and began to hypertrophy when the hCG was no longer effective. Variations in stromal reaction were organ-dependent. When the hCG was administered for more than 14 days, it seemed to have a desensitizing effect; these mechanisms have been discussed.
对公猪进行垂体切除导致血浆睾酮水平迅速下降。注射人绒毛膜促性腺激素（400国际单位/天）可使睾酮血症显著升高（高达16.41纳克/毫升）。这种效果在手术后数天或数月（长达134天）均可获得。在后一种情况下，这种效果是暂时的，因为注射15天后睾酮水平又会再次下降。性靶器官（附睾、精囊、前列腺和尿道球腺）发生了结构变化，在上皮组织中，这种变化与睾酮水平的波动相对应。这些影响在附睾尾部比在其他靶组织中不太明显。在各种靶器官中，结膜肌性基质在手术后形成；当通过人绒毛膜促性腺激素间接刺激上皮时，它根本不会退化或不完全退化，而当人绒毛膜促性腺激素不再起作用时，它开始肥大。基质反应的变化因器官而异。当注射人绒毛膜促性腺激素超过14天时，似乎会产生脱敏作用；这些机制已被讨论。
