Insel T R, van Kammen D P, Cohen R M, Alterman I S, Murphy D L
Biol Psychiatry. 1981 Nov;16(11):1051-7.
The authors evaluated whether the dysphoric effects reported by normals given lithium in several recent studies might also be found in depressed patients if detailed self-ratings were used in a double-blind study design. Nine depressed patients were studied at the end of lithium and placebo treatment trials. No overall adverse effects of lithium were found for the entire group, but individuals showed significant inverse correlations between pretreatment dysphoria and depression and the development of these symptoms with lithium, i.e., the less dysphoric and depressed patients (the more "normal" individuals) did report more adverse symptoms while the patients with higher initial symptom scores rated themselves as improved.
作者评估了在最近的几项研究中，给予正常人锂盐后所报告的烦躁不安效应，如果在双盲研究设计中使用详细的自我评分，是否也会在抑郁症患者中出现。对9名抑郁症患者在锂盐和安慰剂治疗试验结束时进行了研究。整个组未发现锂盐有总体不良影响，但个体显示出治疗前烦躁不安和抑郁与锂盐治疗后这些症状的发展之间存在显著的负相关，即烦躁不安和抑郁程度较轻的患者（更“正常”的个体）确实报告了更多的不良症状，而初始症状评分较高的患者则自评有所改善。
