Bannet J, Belmaker R H, Ebstein R P
Biol Psychiatry. 1981 Nov;16(11):1059-65.
Previous studies of the haloperidol-induced increase in dopamine (DA) receptor number have not emphasized the existence of individual differences. The present study evaluated DA receptor number in individual rat and mouse caudates after haloperidol or drug-free feeding. After 3 months of haloperidol treatment of rats there was a 78% increase in caudate DA receptor number, accompanied by a significantly increased variance in the number of DA receptors in haloperidol-treated compared with control rats. Although three inbred mouse strains (Balb/C, C3H, and CBA) also showed significant increases in DA receptor number after 3 months of haloperidol treatment, no increased variance was observed after haloperidol treatment. Wild-type mice from a genetically heterogenous population showed increases in DA receptor number after chronic haloperidol treatment accompanied by a significantly increased variance in receptor number of the drug-treated group. These findings suggest that pharmacogenetic factors may be important in determining the magnitude of DA receptor response to long-term neuroleptic treatment.
以往关于氟哌啶醇诱导多巴胺（DA）受体数量增加的研究并未强调个体差异的存在。本研究评估了氟哌啶醇处理或无药物喂养后大鼠和小鼠个体尾状核中的DA受体数量。对大鼠进行3个月的氟哌啶醇治疗后，尾状核DA受体数量增加了78%，与对照大鼠相比，氟哌啶醇处理组的DA受体数量方差显著增加。尽管三种近交系小鼠品系（Balb/C、C3H和CBA）在氟哌啶醇治疗3个月后DA受体数量也显著增加，但氟哌啶醇治疗后未观察到方差增加。来自基因异质群体的野生型小鼠在慢性氟哌啶醇治疗后DA受体数量增加，且药物处理组的受体数量方差显著增加。这些发现表明，药物遗传学因素可能在决定DA受体对长期抗精神病药物治疗反应的程度方面很重要。
