Ratner B D
J Biomed Mater Res. 1980 Sep;14(5):665-87. doi: 10.1002/jbm.820140512.
Graft copolymer systems have frequently been suggested for biomedical applications. Since the properties of polymers are altered by the grafting process, thorough characterization is critical, particularly for the surface region of these copolymers. This review briefly discusses the grafting process and then describes characterization procedures for graft copolymers. Gravimetric characterization, thermodynamic measurements, surface chemistry analysis, and surface topographical analysis are considered in detail. Also, the relevance of materials characterization for predicting and understanding the biocompatibility response is discussed. Most of the analytical techniques described are applicable to all biomaterials and should be considered for the routine characterization of materials which will be interfaced with biological systems.
接枝共聚物体系经常被提议用于生物医学应用。由于聚合物的性质会因接枝过程而改变，因此全面表征至关重要，尤其是对于这些共聚物的表面区域。本综述简要讨论了接枝过程，然后描述了接枝共聚物的表征程序。详细考虑了重量表征、热力学测量、表面化学分析和表面形貌分析。此外，还讨论了材料表征对于预测和理解生物相容性反应的相关性。所描述的大多数分析技术适用于所有生物材料，对于将与生物系统接触的材料的常规表征应予以考虑。
