Protsenko V A, Bogadel'nikov I V, Spitsyn I F
Vopr Med Khim. 1978 Nov-Dec;24(6):736-40.
State of tryptic and antienzymatic activities of rabbit blood serum was studied after parenteral administration of trypsin, chymotrypsin, histamine, acetylcholine and kallikrein. Treatment with chymotrypsine led to the most favorable alterations in animals as compared with trypsin and kallikrein effects. Activity of trypsin was increased and the antienzymatic activity was decreased in blood serum after administration of histamine and acetylcholine. This suggests that antiprotease drugs may be used in therapy of diseases, accompanied by increase in content of histamine and acetylcholine.
在经肠胃外给予胰蛋白酶、胰凝乳蛋白酶、组胺、乙酰胆碱和激肽释放酶后，对兔血清的胰蛋白酶和抗酶活性状态进行了研究。与胰蛋白酶和激肽释放酶的作用相比，用胰凝乳蛋白酶处理使动物出现了最有利的变化。给予组胺和乙酰胆碱后，血清中胰蛋白酶的活性增加，抗酶活性降低。这表明抗蛋白酶药物可用于治疗伴有组胺和乙酰胆碱含量增加的疾病。
