Reber H A, Tweedie J H, Maslin S C, Austin J L
Cancer Detect Prev. 1981;4(1-4):443-8.
Pancreatic secretion is abnormal in at least 90% of patients with pancreatic cancer. Any of the standard tests of pancreatic function that employ an exogenous secretin or CCK-like stimulus effectively reveal those abnormalities. However, despite a high sensitivity, the tests lack the specificity necessary to distinguish reliably between pancreatic cancer and chronic pancreatitis. With the current practice of testing pancreatic function in symptomatic patients and in the absence of an identifiable high-risk group within the population, it is unlikely that the established pancreatic function tests will provide a means for the earlier detection of pancreatic cancer.
至少90%的胰腺癌患者存在胰腺分泌异常。任何采用外源性促胰液素或缩胆囊素样刺激物的标准胰腺功能测试都能有效揭示这些异常。然而，尽管这些测试具有高敏感性，但缺乏可靠区分胰腺癌和慢性胰腺炎所需的特异性。鉴于目前在有症状患者中进行胰腺功能测试的做法，且人群中不存在可识别的高危组，现有的胰腺功能测试不太可能提供早期检测胰腺癌的方法。
