Balaba T Ia, Furtseva L N, Shinkarenko I N, Abdurazakov U A
Vopr Med Khim. 1978 Nov-Dec;24(6):818-21.
Impairments in collagen metabolism were observed in patients with Dupuytren's contracture. These impairments were manifested as an increased excretion of hydroxyproline with urine and a decrease in content of the amino acid in tissues of aponeurosis palmaris of the patients. The alterations correlated with the damage caused by contracture. Increased catabolism of collagen appears to be the main reason of the metabolic impairments observed in Dupuytren's contracture, considering the opposite direction of changes in hydroxyproline content in urine and in aponeurosis palmaris of the patients. Impairments in collagen metabolism were of considerable importance in Dupuytren's contracture as demonstrated by the correlation between biochemical alterations and severity of the pathology. The Dupuytren's contracture might be considered as a disease affecting the connective tissue.
在掌腱膜挛缩症患者中观察到胶原代谢受损。这些损害表现为尿中羟脯氨酸排泄增加以及患者掌腱膜组织中该氨基酸含量降低。这些改变与挛缩造成的损伤相关。考虑到患者尿液和掌腱膜中羟脯氨酸含量变化方向相反，胶原分解代谢增加似乎是掌腱膜挛缩症中观察到的代谢损害的主要原因。生化改变与病理严重程度之间的相关性表明，胶原代谢受损在掌腱膜挛缩症中具有相当重要的意义。掌腱膜挛缩症可被视为一种影响结缔组织的疾病。
